Increased Oxidative Stress Induced by Rubus Bioactive Compounds Induce Apoptotic Cell Death in Human Breast Cancer Cells
Effect of C1 and C2 on cytochrome c release and mitochondrial membrane potential. (a) Cytochrome c release. Cytochrome c release is an important measure of cellular damage. C1-treated cells showed significant () release of cytochrome c compared to C2 and control cells. The significant differences between the treated and control groups are shown as ,, and . (b) Mitochondrial membrane potential. Mitochondrial membrane potential evaluation using the flow cytometric analysis of JC-1 fluorometric stain. Percentages of polarized (black) and depolarized (grey) mitochondrial membrane potential were determined and compared to the percentage of the corresponding control cells. C1- and C2-treated cells showed a significant change in mitochondrial membrane potential ().
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