Nrf2 Overexpression for the Protective Effect of Skin-Derived Precursors against UV-Induced Damage: Evidence from a Three-Dimensional Skin Model

Figure 3

Protective effect of nrf2-over-SKPs against UV-mediated 3D skin histological alteration. (a) Sections of the 3D skin model from different groups were stained with H&E (×400). A: normal group; B: model group; C: overexpressed group; D: control group; E: silenced group; F: negative control group. H&E: hematoxylin and eosin. (b) Survival of different SKPs in 3D skin equivalents (×400). A: nrf2-over-SKPs injected into the 3D skin emitted red fluorescence in the overexpressed group; B: lenti-C-SKPs injected into the 3D skin emitted red fluorescence in the control group; C: si-nrf2-SKPs injected into the 3D skin emitted green fluorescence in the silenced group; D: lenti-shNC-SKPs injected into the 3D skin emitted green fluorescence in the negative control group.

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