Antiaging, Stress Resistance, and Neuroprotective Efficacies of Cleistocalyx nervosum var. paniala Fruit Extracts Using Caenorhabditis elegans Model

Figure 2

LMK-P extract can extend the mean and median lifespan of C. elegans. (a) Wild-type nematodes were treated with different concentrations of LMK-P extracts ranging from 1 to 100 μg/ml which could significantly () extend the maximum lifespan of the nematode. Nematodes used as the control which did not receive any extract treatment survived up to 22 days. DMSO was used as a vehicle control which also survived for 22 days. (b) Wild-type nematodes were treated with different concentrations of LMK-P extracts ranging from 1 to 100 μg/ml which could significantly () extend the median lifespan of the nematode. (c) Selective doses which showed maximum extension of lifespan were represented. LMK-P extracts at 10, 20, 30, and 40 μg/ml could extend the lifespan of the nematode up to 27, 30, 29, and 28 days, respectively.

(a)

(b)

(c)