Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress

<div>Inhibition of RNA polymerase I by cx-5461 accelerated AD in mice. (a) Representative images of gross aortic samples are shown. (b) The life-span of each mouse was recorded. Kaplan-Meier survival curve is shown. (c) Representative staining of aorta sections with HE, Masson, and EVG. Graphs show semiquantification of elastic fibre broken grade and collagen/muscle fibre ratio. (d) Representative images of the aortas performed with TUNEL assays, IHC staining with anti-BOP1 antibody and anti-ki-67 antibody. The positive rate is shown (right panels). (e) Western blotting was performed to detect the BOP1, p53, activated caspase 3, <i>α</i>-SMA, and MLC expression of the aortas. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress 