Antioxidant, anti-inflammatory, and vasculoprotective effects by the DPP-4 inhibitor or GLP-1 analog therapy in septic rats. (a) Endothelium-dependent (ACh) relaxation was determined by isometric tension studies in rat aortic ring segments. (b) Aortic expression of inflammatory protein VCAM-1 was assessed by Western blotting analysis and specific antibodies. (c) Levels of 3-NT-positive proteins in plasma were assessed by dot blot analysis and specific antibodies. Representative blots are shown below the densitometric quantification. The data are
from 4-8 (a–c) rats/group.
vs. the control and #
vs. LPS. Adopted from Steven et al. [246
] (with permission from Springer-Verlag Berlin Heidelberg. Copyright © 2015, Springer).