Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 3

Review Article

Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease

Figure 3

Antioxidant, anti-inflammatory, and vasculoprotective effects by the DPP-4 inhibitor or GLP-1 analog therapy in septic rats. (a) Endothelium-dependent (ACh) relaxation was determined by isometric tension studies in rat aortic ring segments. (b) Aortic expression of inflammatory protein VCAM-1 was assessed by Western blotting analysis and specific antibodies. (c) Levels of 3-NT-positive proteins in plasma were assessed by dot blot analysis and specific antibodies. Representative blots are shown below the densitometric quantification. The data are from 4-8 (a–c) rats/group. vs. the control and # vs. LPS. Adopted from Steven et al. [246] (with permission from Springer-Verlag Berlin Heidelberg. Copyright © 2015, Springer).

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