Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer’s Disease, Diabetes, and Obesity

Table 1

Common risk genes identified in genetic meta-analysis of Alzheimer’s disease and in the study of metabolic traits associated with mitochondrial and nuclear mitochondrial variants and genes [38].

Gene SNV	Full gene name	SNV
WWOX	WW domain-containing oxidoreductase	rs1847591
MTCH2	Mitochondrial carrier 2	rs4752856
PSMC3	Proteasome 26S subunit, ATPase 3	Expression regulated by MTCH2 rs4752856
C1QTNF4	C1q and TNF-related 4	Expression regulated by MTCH2 rs3817335
CELF1	CUGBP Elav-like family member 1	Expression regulated by MTCH2 rs7118178
ACP2	Acid phosphatase 2, lysosomal	Expression regulated by NR1H3 rs7120118