The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury

<div>LCA, LIA, and ILF reduced viability when PQ concentration increased. (a) HepG2 cell pretreatment with 10 <i>μ</i>M GLL, LCA, LIA, and ILF for 6 h and exposure to 0-40 <i>μ</i>M PQ for 24 h. (b) A549 cell pretreatment with 10 <i>μ</i>M GLL, LCA, LIA, and ILF for 6.0 h and exposure to 0-40 <i>μ</i>M PQ for 24 h. 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Oxidative Medicine and Cellular Longevity

fig12

Figure 12

Figure 12: The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury 