The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury

<div>Effects of the five compounds on Nrf2, GR, GPX, and NQO1 mRNA expression in A549 cells. (a) A549 cells were incubated with 5 or 10 <i>μ</i>M GLL, ILF, LCA, and LIA and 50 or 100 <i>μ</i>M 18<i>β</i>-GA. Those expression levels were monitored by semiquantitative RT-PCR assay. (b) The expression levels were monitored by quantitative real-time RT-PCR. 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Oxidative Medicine and Cellular Longevity

fig14

Figure 14

Figure 14: The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury 