The Alexipharmic Mechanisms of Five Licorice Ingredients Involved in CYP450 and Nrf2 Pathways in Paraquat-Induced Mice Acute Lung Injury

Figure 7

Licorice reduces PQ accumulation in mice. (a) 2MB@CB[8] was used to investigate the concentration of PQ in plasma. After calculating the concentration of PQ in mouse plasma using the method in the literature, it can be found that PQ accumulation in plasma of mice decreased in a dose-dependent manner after treatment of licorice extract. (b) Fluorescence imaging of PQ in living mice. Excitation wavelengths of were used and the fluorescence emission was detected at in a Berthold chamber. According to real-time in vivo fluorescence imaging of PQ in the living mice, it can be seen that PQ can be readily tracked by using 2MB@CB[8] in living mice. The fluorescence spectra showed that the accumulation of PQ in the licorice extract (60 mg/kg) group was significantly lower than that in the control group. All data are expressed as the error; . CTR: control; MOD: model. Compared with the CTR group, , ; compared with the MOD group, , .

(a)

(b)