MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury

<div>MLN4924 protects against H<sub>2</sub>O<sub>2</sub>-induced oxidative stress and cell death in SH-SY5Y cells via Sirt1. Cell proliferation in response to different doses of either (a) H<sub>2</sub>O<sub>2</sub> or (b) MLN4924 was detected with a cell counting kit-8 (CCK8) assay. (c) SOD activity and (d) MDA concentration in SH-SY5Y cells treated with or without H<sub>2</sub>O<sub>2</sub> and MLN4924/EX527. (e, f) FACS analysis of apoptosis in SH-SY5Y cells treated with or without H<sub>2</sub>O<sub>2</sub> and MLN4924/EX527. 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analyzed by one-way analysis of variance (ANOVA).</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury 