MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury
MLN4924 protects against neurodestruction in SCIR injury. (a–d) Western blot analysis of BCL2, Bax-2, and cleaved caspase-3 in the spinal cord of rats intraperitoneally injected with different doses of MLN4924. (e) The BBB scores of animals treated with different doses of MLN4924 after SCIR injury. . (f) TUNEL immunostaining in the spinal cord of rats which were intraperitoneally injected with different doses of MLN4924. ,,, and . values were analyzed by one-way ANOVA. Scale bar represents 50 μm.
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