MLN4924 Exerts a Neuroprotective Effect against Oxidative Stress via Sirt1 in Spinal Cord Ischemia-Reperfusion Injury
MLN4924 protects against neurodestruction in SCIR via Sirt1. (a–f) Western blot analysis of Sirt1, acetylated FoxO1, BCL2, Bax, and cleaved caspase-3 in the spinal cord of rats treated with or without MLN4924/EX527 after SCIR. (g) Immunohistochemical staining for Sirt1 in the spinal cord of rats treated with or without MLN4924/EX527 after SCIR. MLN4924: 30 mg/kg; Ex527: 1 mg/kg. ,, and . values were analyzed by one-way ANOVA. Scale bar represents 50 μm.
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