|
Feature | Ref. |
|
Structural domains |
Ankyrin repeats | [123] |
Coiled coil |
Protein destabilization motif (PEST) |
Nuclear localization signal (NLS) |
Posttranslational modifications |
Phosphorylation by Akt2 kinase | [15] |
Proteolytic cleavage by μ-calpain | [9] |
Expression profile |
| [4, 19, 123, 124] |
Type I (slow) skeletal muscle fibers | [8, 123] |
Localized in nuclei of myoblasts and cytoplasm of myotubes | [123] |
Migrate from myofibrils to nucleus after muscle injury | [10] |
Proposed functions |
Stress response in muscle (stretch, denervation, eccentric contractions, fatiguing jumping and other types of exercise, and injury) | [8, 10, 16, 46, 47, 49, 50, 55] |
Muscle adaptation | [7, 10, 16, 20, 46, 47, 49, 50, 125, 126] |
Transcriptional regulation | [1, 10] |
Communication between the sarcoplasm and the nucleus | [1] |
Myogenesis and myogenic differentiation | [11, 13, 14] |
Inflammatory response | [12] |
Interacting proteins |
Titin | [7] |
Telethonin | [1] |
ZASP | [30] |
Calpain 3 | [9] |
Akt2 | [15] |
A-type lamins (lamin A, prelamin A, and lamin C) | [98] |
Proteins with PDZ and SH3 domains, including ZO-1 and β1-syntrophin | [20] |
Transcription factors, including YB1, p53, PML, PAX6, NFIL3, and MECP2 | [20] |
Pathways affected by Ankrd2 silencing in human myoblasts |
Intercellular communication | [20] |
Cytokine-cytokine receptor interaction |
Focal adhesion |
Tight junction |
Gap junction |
Regulation of actin cytoskeleton |
Signaling involved in intracellular communication |
Calcium |
Insulin |
MAPK |
p53 |
TGF-β |
Wnt |
|