Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

Figure 2

OCA pretreatment alleviated E2-induced cholestasis. All pregnant mice except controls were s.c. injected with E2 (0.625 mg/kg) once daily from GD13 to GD17. In the OCA+E2 groups, pregnant mice were administered with OCA (5 mg/kg) by gavage once daily from GD12 to GD17. All dams were sacrificed on GD18. (a) Serum total bile acid levels. (b) Serum ALT and AST. (c) Maternal liver weight and liver coefficient (liver weight/body weight). (d) Maternal liver sections were stained with H&E. Representative images were shown. Original magnification: ×400. Hepatic cytoplasmic organelles were loosening after E2 treatment (arrow). Hepatocyte atrophy (oval). Original magnification: ×400. Quantified data were expressed as ( for each group). , .

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