Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice

<div>OCA pretreatment alleviated fetal intrauterine growth restriction during E2-induced cholestasis. All pregnant mice except controls were s.c. injected with E2 (0.625 mg/kg) once daily from GD13 to GD17. In the OCA+E2 groups, pregnant mice were administered with OCA (5 mg/kg) by gavage once daily from GD12 to GD17. All dams were sacrificed on GD18. (a) Fetal mortality per litter. (b) Fetal weight per litter and fetal crown-rump length per litter. (c) Rate of IUGR per litter. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Obeticholic Acid Protects against Gestational Cholestasis-Induced Fetal Intrauterine Growth Restriction in Mice 