TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5)
Representative immunohistochemical (IHC) staining for TRPV1 (a) and TRPA1 (b) as indicated by the brown stains (arrows) in mouse lung tissue sections from PBS-pretreated, AMG9810-pretreated, A967079-pretreated, and AMG9810+A967079-pretreated PBS-instilled mice and from PBS-pretreated, AMG9810-pretreated, A967079-pretreated, and AMG9810+A967079-pretreated PM2.5-instilled mice (μm). Individual and mean immunostaining scores of TRPV1 (c) and TRPA1 (d) measured from lung immunohistochemical sections. Western blot analysis of the relative protein expression of TRPV1 (e) and TRPA1 (f) to GAPDH in mouse lung tissue homogenates (f). ,, and compared with PBS+PM2.5 mice.