N-Acetyltransferase 10 Enhances Doxorubicin Resistance in Human Hepatocellular Carcinoma Cell Lines by Promoting the Epithelial-to-Mesenchymal Transition

Figure 7

Remodelin enhances the efficacy of doxorubicin in a xenograft model of HCC in nude mice. (a) Mice were euthanized after 2 weeks of treatment and tumors were dissected. (b) Volume of tumor xenografts in the control group (black) and groups treated with remodelin (red), doxorubicin (green), or remodelin plus doxorubicin (brown). Relative tumor volume ratios are shown (% of original volume when therapy was initiated). (c) Body weight of mice in the control group (black) and groups treated with remodelin (red), doxorubicin (green), or remodelin plus doxorubicin (brown). Relative body weight ratios are shown (% of original volume when therapy was initiated). (d) Tumor proliferation rates. (e) Immunohistochemical analysis of expression of the EMT-related markers E-cadherin and vimentin in the xenograft tumors. Values are , ; , , and for control vs. remodelin, doxorubicin, or remodelin plus doxorubicin; , , and for doxorubicin plus remodelin vs. doxorubicin or remodelin alone.

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