Research Article
Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss
Figure 4
Berberine ameliorates Aβ1-42-induced abnormalities in mitochondrial trafficking in primary cultured hippocampal neurons. (a) Percentages of stationary, moving, moving anterograde, and moving retrograde mitochondria were compared with those of total mitochondria, respectively. (b) Percentages of anterograde and retrograde mitochondria were compared with the total amount of movable mitochondria, respectively. (c) Representative kymograph images of vehicle-, oligomeric Aβ1–42- (0.5 μM), or oligomeric Aβ1-42+berberine- (1.0 μM) treated axonal mitochondrial movement. Scale . (d) Average transport velocity of anterograde and retrograde mitochondrial was calculated. vs. the vehicle-treated group, vs. the Aβ-treated group. Values are expressed as the error of the mean of 4 independent experiments; 6 axons per group.
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