Research Article
Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss
Figure 5
Berberine attenuates the Aβ1-42-induced reactive oxygen species generation and malondialdehyde elevation in primary cultured hippocampal neurons. (a) Representative images of DCF staining in hippocampal neurons for the indicated treatment. Scale . (b) Quantification of DCF intensities in (a). (c) MDA were significantly elevated in Aβ1-42-treated neurons compared to vehicle-treated neurons and partially restored in berberine-treated neurons in a dose-dependent manner. Values are expressed as the error of the mean of 4 independent experiments. and vs. vehicle-treated group, and vs. the Aβ-treated group. Aβ: cells were treated with Aβ1-42 at 0.5 μM.
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