Berberine Alleviates Amyloid <i>β</i>-Induced Mitochondrial Dysfunction and Synaptic Loss

<div>Berberine protects against A<i>β</i><sub>1–42</sub>-induced synaptic loss in primary cultured hippocampal neurons. Neurons treatment with vehicle, oligomeric A<i>β</i><sub>1–42</sub> (0.5 <i>μ</i>M), or oligomeric A<i>β</i><sub>1-42</sub>+berberine (1.0 <i>μ</i>M) were immunostained for MAP2 and synaptophysin. (a) Representative images for neurons and synapses showed colocalization of synaptophysin and MAP2. Scale <span class="nowrap"><svg height="12.7373pt" id="M76" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 64.8 12.7373" width="64.8pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 449 249 446 233 439L152 404ZM152 374C170 384 202 393 230 393C313 393 382 326 382 213C382 97 330 26 246 26C194 26 165 62 158 81C154 91 152 101 152 116V374Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.669,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 365 44 353 44 339C44 315 69 296 87 296C101 296 111 303 116 319C124 349 133 371 145 385C156 397 171 404 190 404C241 404 275 364 275 291V274C253 256 180 229 120 209C65 190 39 159 39 110C39 47 88 -12 159 -12C189 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602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.24,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,41.204,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,47.444,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. the A<i>β</i>-treated group. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Berberine Alleviates Amyloid <i>β</i>-Induced Mitochondrial Dysfunction and Synaptic Loss 

Oxidative Medicine and Cellular Longevity

Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss

Figure 6