The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO<sub>2</sub> NPs in Neurogenic Cells

<div>(a) Intracellular superoxide anion was determined by DHE after U251 cells, and SK-N-SH cells were treated with 1 <i>μ</i>g/ml and 100 <i>μ</i>g/ml of TiO<sub>2</sub> NPs, respectively. (b) mTOR, p-mTOR, and GCLc protein levels were determined by western blotting assay after two kinds of cells were treated with 1 <i>μ</i>g/ml and 100 <i>μ</i>g/ml of TiO<sub>2</sub> NPs. (c) GSH levels were determined after two kinds of cells were treated with 1 <i>μ</i>g/ml and 100 <i>μ</i>g/ml of TiO<sub>2</sub> NPs. The results were from three panel samples of each experiment. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO<sub>2</sub> NPs in Neurogenic Cells 

Oxidative Medicine and Cellular Longevity

The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO2 NPs in Neurogenic Cells

Figure 4

The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO₂ NPs in Neurogenic Cells