The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO<sub>2</sub> NPs in Neurogenic Cells

<div>(a) GCLc protein levels and superoxide anion levels were examined after U251 and SK-N-SH cell lines were treated with 1 <i>μ</i>g/ml of TiO<sub>2</sub> NPs and 1 <i>μ</i>g/ml of TiO<sub>2</sub> NPs+RAPA. (b) mTOR protein levels and superoxide anion levels were determined after two kinds of cells were treated with 100 <i>μ</i>g/ml of TiO<sub>2</sub> NPs and 100 <i>μ</i>g/ml of TiO<sub>2</sub> NPs+50 <i>μ</i>M of Mn(III)TBAP; GAPDH was used as a protein loading control. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO<sub>2</sub> NPs in Neurogenic Cells 

Oxidative Medicine and Cellular Longevity

The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO2 NPs in Neurogenic Cells

Figure 6

The mTOR/GCLc/GSH Pathway Mediates the Dose-Dependent Bidirectional Regulation of ROS Induced by TiO₂ NPs in Neurogenic Cells