Nanoencapsulated Quercetin Improves Cardioprotection during Hypoxia-Reoxygenation Injury through Preservation of Mitochondrial Function

Figure 5

Assessment of mitochondrial O₂^- and H₂O₂ production in H9c2 cells as a response to AA after 24 h quercetin or PLGA-quercetin treatments. (a) Description of the ROS production in the mitochondria due to AA stimulus. (b) Mitochondrial O₂^- production. PLGA-quercetin shows a better dose-dependent O₂^- suppression. (c) Mitochondrial H₂O₂ production rate. Treatments with quercetin or PLGA-quercetin are dose-dependent, with PLGA-quercetin presenting a better reduction of O₂^- and H₂O₂. In (b) and (c), lines were fitted to equation (6). Statistical significance versus H-R cells, denoted as ^a, means .

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(b)

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