Multiorgan Development of Oxidative and Nitrosative Stress in LPS-Induced Endotoxemia in C57Bl/6 Mice: DHE-Based In Vivo Approach

Figure 4

Markers of the organ injury and systemic inflammation in a murine model of endotoxemia, 6 and 12 hours after LPS challenge. Liver damage—ALT (a) and AST (b), kidney damage—creatinine (c), and systemic inflammation—SAA (d). Data are presented as or , and statistical significance was tested using one-way ANOVA post hoc LSD’s test or Kruskal-Wallis, post hoc Dunn’s, depending on the distribution and homoscedasticity of data. values <0.05 were considered significant, with <0.05, <0.01, and <0.001 versus the control group and ○ <0.05 and ○○ <0.01 versus the LPS 6 h group.

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