Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function

Figure 2

SCM-198 reduced neuron loss after I/R insult. (a) FJB staining of brain sections after reperfusion. Representative pictures of FJB staining of brain sections after reperfusion. No FJB-positive cells were found in the control group. Vast degenerating neurons were detected in the peri-ischemic regions of the tMCAO group. SCM-198 significantly reduced the number of degenerating neurons. (b) The quantitative analysis of the number of degenerating neurons. . Values are expressed as . versus control group, versus tMCAO group (). (c) Immunofluorescence staining for NeuN after ischemia reperfusion. SCM-198 could reduce neuron loss in the ipsilateral brain cortex. .

(a)

(b)

(c)