Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway

Figure 5

GE activated AMPKα to prevent DOX-induced toxicity in vitro. (a, b) Western blot and quantitative results in vivo () and in vitro (). (c) Representative images of TUNEL and the quantitative results (). Arrows indicate TUNEL-positive cells. (d) Cell viability after GE (100 μmol/l) for 12 h (). (e) LDH levels of four groups (). (f) ROS level detected by DCF-DA in the indicated group (). (g) Levels of MDA (). (h) Western blot and quantitative results of Nrf2 and GAPDH in H9C2 cells (). Values represent the . In (a), versus saline, versus DOX; in (b), versus PBS. In others, versus DOX.

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