Association between Pretreatment Serum Uric Acid Levels and Progression of Newly Diagnosed Primary Angle-Closure Glaucoma: A Prospective Cohort Study
Table 1
Demographic, ophthalmic characteristics, and serum UA levels of PACG.
Factors
PACG ()
Progressing group ()
Nonprogressing group ()
value
Age, mean (SD) (years)
58.30 (15.24)
59.81 (15.19)
58.09 (15.27)
0.657
Sex, male/female
22/42
12/20
10/22
0.599
BMI, mean (SD) (kg/m2)
23.96 (3.24)
23.83 (3.16)
24.19 (3.46)
0.720
SBP, mean (SD) (mmHg)
129.29 (15.13)
127.94 (14.68)
131.61 (16.04)
0.418
DBP, mean (SD) (mmHg)
75.73 (10.78)
78.42 (9.42)
71.11 (11.66)
0.021
Diabetes, yes/no
8/56
5/27
3/29
0.708
Hypertension, yes/no
10/54
6/26
4/28
0.491
Baseline IOP, mean (SD) (mmHg)
31.12 (9.13)
32.17 (8.59)
30.10 (9.64)
0.372
Baseline VCDR, mean (SD)
0.60 (0.22)
0.59 (0.21)
0.64 (0.26)
0.449
Baseline CCT, mean (SD) (μm)
550.47 (42.33)
554.10 (43.72)
542.08 (39.30)
0.399
Baseline ACD, mean (SD) (mm)
2.20 (0.76)
2.19 (0.78)
2.24 (0.74)
0.851
Baseline AL, mean (SD) (mm)
22.87 (1.43)
23.22 (1.51)
22.18 (0.98)
0.025
Baseline MD, mean (SD) (dB)
12.98 (7.93)
12.28 (8.73)
13.52 (7.35)
0.564
Baseline MS, mean (SD) (dB)
14.73 (8.18)
15.30 (9.16)
14.29 (7.43)
0.650
Pretreat UA, mean (SD) (mmol/l)
0.286 (0.075)
0.258 (0.069)
0.314 (0.069)
0.002
Pretreat UA (male), mean (SD) (mmol/l)
0.347 (0.061)
0.308 (0.043)
0.394 (0.044)
<0.001
Pretreat UA (female), mean (SD) (mmol/l)
0.254 (0.060)
0.228 (0.065)
0.278 (0.043)
0.007
Follow-up UA, mean (SD) (mmol/l)
0.286 (0.074)
0.266 (0.075)
0.305 (0.069)
0.033
Follow-up UA (male), mean (SD) (mmol/l)
0.345 (0.062)
0.314 (0.061)
0.381 (0.040)
0.008
Follow-up UA (female), mean (SD) (mmol/l)
0.255 (0.061)
0.237 (0.069)
0.271 (0.049)
0.071
Follow-up IOP, mean (SD) (mmHg)
21.99 (8.63)
29.30 (5.05)
14.90 (4.35)
<0.001
Follow-up MD, mean (SD) (dB)
13.94 (7.32)
14.00 (8.20)
13.89 (6.69)
0.956
Duration of follow-up, (range) (month)
12.77 (3~28)
6.16 (3~12)
20.91 (12~28)
<0.001
Treatment (% yes)
100
100
100
1.00
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; IOP: intraocular pressure; VCDR: vertical cup-disc ratio; CCT: central corneal thickness; ACD: anterior chamber depth; AL: axial length; MD: visual field mean deviation; MS: visual field mean sensitivity; SD: standard deviation; UA: uric acid. Independent Student’s -test, Fisher exact test, and tests were used for comparison of patient characteristics between the progressing group and nonprogressing group.
