Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 6

Research Article

Icariin Inhibits AGE-Induced Injury in PC12 Cells by Directly Targeting Apoptosis Regulator Bax

Figure 6

ICA regulated the biological activity of Bax. (a) ICA inhibited Bax transfer to mitochondria. (b) Bax dimer was detected by chemical cross-linking technology. (c and d) The reverse effects of Bax gene silencing on ICA-mediated antioxidative stress and neuroprotection were detected using MitoSOX and MTT assay. Scale  μm. Data were presented as from independent experiments performed in triplicate. relative to the control group; relative to the model group. N.S., not significant.

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