Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia

Figure 2

Lung glutathione levels. Pups were dosed with either saline or 25 mg/kg ATG and exposed to room air (RA) or hyperoxia (HO) for up to 7 days (-6). Total (a–c) and oxidized glutathione levels were determined (d, e) as described, and ratios of total to oxidized glutathione (adjusted for reduced glutathione equivalents) were calculated (g–i). vs. saline/RA; vs. ATG/RA.

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