Research Article
Nutritional Preconditioning of Apigenin Alleviates Myocardial Ischemia/Reperfusion Injury via the Mitochondrial Pathway Mediated by Notch1/Hes1
Figure 5
Effects of Api pretreatment on cardiomyocyte viability and LDH activity after SI/R injury. The primary cardiomyocytes were cultured with different concentrations of pretreated Api (10, 20, 40, and 80 μM) for 24 h, then normally cultured for 19 h prior to SI/R injury. Api pretreatment increased cell viability (a) and reduced LDH activity (b) in a concentration-dependent manner. Values are presented as of 8 individual experiments. (a) vs. control group; (b) vs. SI/R group.
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