High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

Table 3

Differential gene expression of mitochondrial transcripts after high LDL treatment. Comparison of the expression of mitochondrial protein coding genes and ribosomal RNAs between untreated cells and cells treated with high LDL. The L2FC (log 2-fold change) states the average difference in gene expression between both treatments. Positive L2FC values denote upregulation by high LDL; negative values denote downregulation. A Wald test from DESeq2 was used to calculate the significance of the change in the expression. The adjusted values take the number of tested genes into account.

Gene name	Ensembl gene ID	L2FC	value	Adjusted value
MT-RNR1	ENSG00000211459	1.86
MT-RNR2	ENSG00000210082	1.52
MT-ND6	ENSG00000198695	1.67
MT-ND1	ENSG00000198888	1.34
MT-ND4	ENSG00000198886	1.29
MT-ND3	ENSG00000198840	1.33
MT-CO1	ENSG00000198804	1.34
MT-CO2	ENSG00000198712	1.19
MT-ATP6	ENSG00000198899	1.00
MT-CYB	ENSG00000198727	1.01
MT-ND2	ENSG00000198763	0.90
MT-CO3	ENSG00000198938	0.87
MT-ND4L	ENSG00000212907	1.04
MT-ND5	ENSG00000198786	1.40
MT-ATP8	ENSG00000228253	0.82