Coenzyme Q10 Ameliorates Pancreatic Fibrosis via the ROS-Triggered mTOR Signaling Pathway

Figure 6

(a) Western blotting analysis for p-PI3K, p-AKT, and p-mTOR expression levels of activated PSCs was performed after 72 h with CoQ10 treatment, as well as the addition of LY294002 (PI3K-specific inhibitor), perifosine (AKT-specific inhibitor), or rapamycin (mTOR-specific inhibitor). (b) Quantification of western blots for p-PI3K, p-AKT, and p-mTOR expression levels in the various groups with the addition of LY294002 compared to the normal control group (; ). (c) Quantification of western blots for p-PI3K, p-AKT, and p-mTOR expression levels in the various groups with the addition of perifosine compared to the normal control group (; ). (d) Quantification of western blots for p-PI3K, p-AKT, and p-mTOR expression levels in the various groups with the addition of rapamycin compared to the normal control group (; ).

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