Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 6

Research Article

Differential Modulation of NF-κB in Neurons and Astrocytes Underlies Neuroprotection and Antigliosis Activity of Natural Antioxidant Molecules

Figure 6

Modulation of neuronal transcription factor activity by glial activation and RSV. (a) Protein-DNA array of nuclear extracts prepared from cortical neurons treated for 2 h with CM (from LPS-stimulated astrocytes), RSV (10 μM), or CM-LPS plus RSV. The grid for location of transcription factors (https://www.biocat.com/bc/pdf/MA1210_MA1215_Protein_DNA_Arrays). (b) Quantitation of transcription factors. (c) Bar graph for quantitative analysis of the ratio RSV/CTR and CM-LPS+RSV/CM-LPS. Light grey square = no change or reduction versus CTR; dark grey square = induction versus CTR (); grey square = induction versus CTR (>2‐fold).

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