Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization

<div>Mitochondrial fission in axonal degeneration of the glial lamina in glaucomatous DBA/2J mice. (a) Representative TEM micrographs showed normal healthy morphology of axons and myelins, as well as astrocytic processes in the glial lamina of aged matched nonglaucomatous control D2-<i>Gpnmb<sup>+</sup></i> mice. However, representative TEM micrographs showed a significant loss of axon and myelins as well as disrupted astrocytic processes in the glial lamina of glaucomatous DBA/2J mice. Scale bars, 20 nm. (b) Representative 3D reconstruction micrographs from a SBEM data set showed highly fragmented mitochondria (several colors) in the axons of the glial lamina in glaucomatous DBA/2J mice. The arrow indicates damaged axon bundle. Scale bars, 10 <i>μ</i>m (C) and 1 <i>μ</i>m (A and B).</div>

Oxidative Medicine and Cellular Longevity

fig2

Figure 2

Figure 2: Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization 

Figure 2 | Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization 