Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization

<div>Effects of PKA inhibition on mitochondrial morphology in ONH astrocytes against combined oxidative stress and cAMP elevation. ONH astrocytes exposed to H<sub>2</sub>O<sub>2</sub> (50 <i>μ</i>M) were cotreated with dbcAMP (100 <i>μ</i>M) and/or H89 (10 <i>μ</i>M) for 1 h. (a) MitoTracker Red staining of mitochondria in ONH astrocytes treated with H<sub>2</sub>O<sub>2</sub> and/or dbcAMP. Scale bars, 10 <i>μ</i>m. (b) Quantitative analysis of mitochondrial number and lengths in ONH astrocyte somas. Note that PKA inhibition restores mitochondrial number and lengths in ONH astrocytes against combined oxidative stress and cAMP elevation. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization 

Figure 6 | Inhibition of cAMP/PKA Pathway Protects Optic Nerve Head Astrocytes against Oxidative Stress by Akt/Bax Phosphorylation-Mediated Mfn1/2 Oligomerization 