Aspirin Eugenol Ester Reduces H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis

<div>AEE ameliorated lysosomal disorder induced by H<sub>2</sub>O<sub>2</sub>. (a, b) AEE reduced the expression of mature CTSD induced by H<sub>2</sub>O<sub>2</sub>. (c) AEE reduced the increase in CTSD activity induced by H<sub>2</sub>O<sub>2</sub>. The high-density fluorescence of LysoTracker Red was indicated by green arrows. (d, e) AEE enhanced the stability of the lysosomal membrane disrupted by H<sub>2</sub>O<sub>2</sub> ((d) <svg height="8.69875pt" id="M12" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.34882 38.6238 8.69875" width="38.6238pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,15.386,0)"><path d="M528 54L331 254L528 455L492 493L294 291L96 493L60 455L257 254L60 54L96 16L294 217L492 16L528 54Z"></path></g><g transform="matrix(.013,0,0,-0.013,25.922,0)"><path d="M456 178V225H360V632H320C217 496 115 347 20 206V178H280V106C280 40 276 34 189 27V0H445V27C364 34 360 39 360 106V178H456ZM280 225H82C149 335 214 431 278 520H280V225Z"></path></g><g transform="matrix(.013,0,0,-0.013,32.162,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg> power). “+” including the treatment in the HUVECs; “-”excluding the treatment on the HUVECs. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Aspirin Eugenol Ester Reduces H<sub>2</sub>O<sub>2</sub>-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis 

Oxidative Medicine and Cellular Longevity

Aspirin Eugenol Ester Reduces H2O2-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis

Figure 3

Aspirin Eugenol Ester Reduces H₂O₂-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis