Aspirin Eugenol Ester Reduces H₂O₂-Induced Oxidative Stress of HUVECs via Mitochondria-Lysosome Axis

Figure 4

AEE alleviated the mitochondrial dysfunction induced by H₂O₂. (a, b) AEE reduced the collapse of the mitochondrial membrane potential induced by H₂O₂ ((a) power). (c, d) AEE reduced the generation of cellular and mitochondrial ROS induced by H₂O₂ (upper part of (c): power; lower part of (c): power); “+” with the treatment in the HUVECs, “-” excluding the treatment on the HUVECs. (e, f) AEE prevented the release of Cyt c from mitochondria ((e) power). Values are expressed as , ; , compared with the normal group; ^#, compared with the group of H₂O₂ alone (one-way ANOVA followed with Duncan’s multiple comparisons).

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