Proresolving Lipid Mediators: Endogenous Modulators of Oxidative Stress

Table 2

Main endogenous enzymatic and nonenzymatic antioxidant systems.

Antioxidant	Function	Localization
SOD	Removal of ^·O2^-	Mitochondria
Catalase	Dismutation of H2O2	Peroxisomes
Glutathione peroxidase	Removal of H2O2	Cytoplasm
Glutathione reductase	Reduction of glutathione	Cytoplasm
Peroxiredoxin	Removal of H2O2, ONOO^-, hydroperoxides	Cytoplasm, plasma membrane
Transferrin/ferritin/; lactoferrin/ceruloplasmin	Scavenging of transition metals	Plasma and cytoplasm
Glutathione	Scavenging of reactive species	Ubiquitous
Uric acid	Scavenging of reactive species	Ubiquitous
Pyruvate	Scavenging of reactive species	Ubiquitous
Amino acids	Scavenging of reactive species	Ubiquitous