Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF

Figure 6

Nrf2 and GSH participate in curcumin-induced HCC protection. (a) HepG2 cells were silenced by control shRNA (sh-control), shRNA targeting HIF-1α (sh-HIF-1α), or shRNA targeting CTGF (sh-CTGF); nuclear Nrf2 protein levels of HepG2 cells were analyzed by western blot. (b) Glutathione (GSH) and glutathione disulfide (GSSG) levels were evaluated in HepG2 cells. versus St Med group (), versus CM (). All data are representative of at least three independent experiments.

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