Research Article
Decreased Nuclear Ascorbate Accumulation Accompanied with Altered Genomic Methylation Pattern in Fibroblasts from Arterial Tortuosity Syndrome Patients
Figure 3
Global 5-methylcytosine and 5-hydroxymethylcytosine levels in the genome of fibroblasts derived from healthy controls and arterial tortuosity syndrome patients; 5-methylcytosine (5-mC) levels of fibroblasts derived from controls and arterial tortuosity syndrome patients, with or without ascorbate (AA) supplementation, measured with MethylFlash ELISA Colorimetric DNA kit (a) or with liquid chromatography-tandem mass spectrometry (LC-MS/MS, (b)). 5-Hydroxymethylcytosine (5-hmC) levels of control and patient fibroblasts, with or without AA supplementation, measured with ELISA kit (c) or LC-MS/MS (d). Data are presented as , -7, .
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