Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 6

Research Article

Modulations of Histone Deacetylase 2 Offer a Protective Effect through the Mitochondrial Apoptosis Pathway in Acute Liver Failure

Figure 6

CAY10683 alleviates liver damage through regulating the mitochondrial apoptotic pathway in ALF rats. (a) The RFU value was detected by the purified MPTP fluorescence detection kit. (b) The mRNA level of bcl2 and bax mRNA levels were detected by RT-PCR. (c-e) The protein expressions of HDAC2, cyt c in mitochondrion, cyt c in cytosol, caspase 3, c-caspase 3, caspase 9, c-caspase 9, apaf1, bcl2, and bax were detected by western blot. (f) The protein expressions of AH3 and H3 were detected by western blot. , compared with the control group. , compared with the LPS/D-gal-treated model group.

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