Melatonin Reduces Androgen Production and Upregulates Heme Oxygenase-1 Expression in Granulosa Cells from PCOS Patients with Hypoestrogenia and Hyperandrogenia

Table 3

Embryo development of oocytes after intracytoplasmic spermatozoa injection (ICSI).

	Number of MI & GV-oocytes ()/patients ()	MII oocyte rate (%)	Fertilization rate (%)
Control	35/22	^a	^ab
PCOS	26/17	^b	^b
M-control	46/22	^a	^a
M-PCOS	27/15	^a	^a

Note: ^a,bdifferent superscript letters in the same column indicate significantly different values between different groups (). MI or GV refer to the immature states of oocyte. is the number of immature oocytes. is the patient’s number who provides oocytes. MII is the mature state of oocyte. M represents melatonin treatment.