FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling

Figure 9

Proposed mechanistic model of FA-97 protects against oxidative stress-mediated neuronal damage and apoptosis. Our findings demonstrated a scenario where FA-97 promotes the nuclear translocation of Nrf2 and the expression of its downstream target proteins HO-1 and NQO-1, to increase the SOD and GSH level, reduce the ROS and MDA level, and enhance the oxidant resistance, and eventually protects against oxidative stress-mediated neuronal cell apoptosis and scopolamine-induced cognitive impairment.