Competing Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer

Figure 11

Econazole inhibited prostate tumor growth in the xenograft mouse model and had no toxic effect on the main organs (original magnification, 100x). (a) Ki67 immunohistochemical staining showed that the expression of Ki67 in the econazole treatment groups was significantly lower than that in the control group. (b) HE staining of paraffin-embedded sections of the heart, liver, kidney, lung, and spleen indicated that econazole inhibited the growth of tumors at 40 mg/kg and 80 mg/kg and also did not produce toxic side effects on nude mice.

(a)

(b)