Competing Endogenous RNA and Coexpression Network Analysis for Identification of Potential Biomarkers and Therapeutics in association with Metastasis Risk and Progression of Prostate Cancer

Figure 6

Dysfunctional coexpression network construction in PCa lymphatic metastasis. (a) Dendrograms produced by average linkage hierarchical clustering of genes. Modules are defined as clusters of densely interconnected genes. Hierarchical clustering of module eigengenes that summarize the modules found in the clustering analysis. Branches of the dendrogram group together eigengenes that are positively correlated. The extent of gene conservation in the datasets was represented by the same module colors. The top two enriched modules were presented as (b) turquoise and (c) blue. The genes of “highly connected gene” inside coexpression modules tend to be hub genes.

(a)

(b)

(c)