Sailuotong Capsule Prevents the Cerebral Ischaemia-Induced Neuroinflammation and Impairment of Recognition Memory through Inhibition of LCN2 Expression

Figure 2

The ischaemic penumbra area in the box was assessed for neuronal apoptosis using HE staining. Cortex sections and hippocampal regions stained with HE presented with neuronal loss and signs of cerebral edema, and swollen cells were observed in the ipsilateral hippocampus; plentiful apoptotic neurons were observed with karyopyknosis, cell gaps, and debris. SLT (33 mg/kg, daily) significantly alleviated the symptoms of apoptosis in a dose-dependent manner.

(a)

(b)

(c)

(d)