The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury

Figure 2

The participation of SIRT1 in protecting the liver from drug-induced liver injury (DILI). DILI results in the sharp increase of ROS (reactive oxygen species) mainly by repressing mitochondrial fatty acid oxidation (FAO) and damaging mitochondrion. Multiple signaling pathways are stimulated by SIRT1 such as Nrf2, AMPK/PGC-α, and FoxOs/autophagy, to exert its inhibitory effects on DILI.