| Compounds | Toxic | Mechanisms | Ref. | Name | Dosage | Name | Dosage |
| Dioscin | 80, 40, and 20 mg/kg (mice) 60, 30, and 15 mg/kg (rats) | DMN | 14 mg/mg (mice) 10 mg/mg (rats) | SIRT1↑, Nrf2↑, and Bcl-2↑ p53↓, Fas↓, and FasL↓ | [99] | GSO | 3.7 g/kg (rats) | CCl4 | 1 ml/kg (rats) | SIRT1↑ NF-κB↓, CYP2E1↓ | [100] | Luteolin | 100 mg/kg (mice) | HgCl2 | 4 mg/kg (mice) | SIRT1↑, Nrf2↑ p38↓, TNF-α↓ | [72] | SalB | 15, 30 mg/kg (rats) | Ethanol | 6 g/kg (rats) | SIRT1↑ p53↓, NF-κB↓ | [96] | RUE | 100 mg/kg (mice) | Ethanol | 1 g/kg (mice) | SIRT1↑, AMPK↑ p65↓, SREBP-1↓ | [89] | MFA | 5, 10, and 10 mg/kg (rats) | Ethanol | 5% (, rats) | SIRT1↑, PPAR-α↑ MAPK↓, p-ACC↓ | [67] | TQ | 20, 40 mg/kg (mice) | Ethanol | 5 g/kg (mice) | SIRT1↑, AMPK↑ | [74] | CA | 20, 40 mg/kg (rats) | Ethanol | 6 g/kg (rats) | SIRT1↑ p66Shc↓ | [105] | Resveratrol | 500 mg/kg (Rats) | HFCS | 20% (, rats) | SIRT1↑, IRS-1↑ iNOS↓ | [77] | Quercetin SRT1720 Resveratrol | 50 mg/kg (rats) 5 mg/kg (rats) 2.3 mg/kg (rats) | D-GalN LPS | 400 mg/kg (rats) 10 μg/kg (rats) | SIRT1↑, HO-1↑ Bilirubin↓ | [35] | Melatonin | 0.5 μM (HepG2) | Cadmium | 2.5, 5, and 10 μM (HepG2) | SIRT1↑ Ac-PGC-1α↓ | [88] | STR1720 | 10, 20 mg/kg (mice) | EE | 10 mg/kg (mice) | SIRT1↑, FXR/HNF1α↑ IL-6↓, TNF-α↓ | [103] | SalA | 15, 25 mg/kg (mice) | ConA | 18 mg/kg (mice) | SIRT1↑ p66Shc↓ | [97] | Resveratrol | 25, 50, and 100 mg/kg (mice) | APAP | 400 mg/kg (mice) | SIRT1↑, cyclin D1↑ p53↓, CYP2E1↓ | [23] | Resveratrol CAY10591 | 30 mg/kg (rats) 0.5 mg/kg (rats) | APAP | 1 g/kg (rats) | SIRT1↑ | [24] | Resveratrol | 100 mg/kg (mice) | INH RIF | 50 mg/kg (mice) 100 mg/kg (mice) | SIRT1↑ PPAR-γ↓ | [71] |
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