Waterpipe Smoke Exposure Triggers Lung Injury and Functional Decline in Mice: Protective Effect of Gum Arabic

Figure 8

Airway hyperresponsiveness. The airway resistance (), after increasing concentrations of methacholine (MCh) (0–40 mg/ml), was measured via the forced oscillation technique (flexiVent), at the end of the one-month exposure period to either air (control) or waterpipe smoke (WPS) with or without GA administration (15% in drinking water). Dose-response relationship of total respiratory system resistance to increasing doses of MCh (a). From the resistance MCh dose-response curve in (a), an index of airway responsiveness was calculated as the slope of the linear regression using 0–40 mg/ml concentrations (b). Data are (-9).

(a)

(b)