Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer

Table 1

Some HIF inhibitors and targets.

Agents	Inhibitory mechanisms	Targeting HIF-1	Targeting HIF-2	Reference no.
EZN-2968	HIF-1 mRNA expression	√	—	Jeong, et al., [60]
EZN-2208	HIF-1 mRNA expression	√	—	Coltella, et al., [61]
Topotecan	HIF-1 mRNA translation	√	—	Rapisarda, et al., [62]
HIF-1α inhibitor	HIF-α transcriptional activity	√	√	Cui, et al., [63]
PX-12	HIF-α transcriptional activity	√	—	Raninga, et al., [64]
Acriflavine	HIF transcriptional activity	√	√	Lee, et al., [40, 41]
Echinomycin	HIF DNA binding	√	—	Yu, et al., [65]